Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of Fibrosis in HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease.

Journal of the American Society of Nephrology : JASN - 1 Oct 2018

Chan Siu Chiu, Zhang Ying, Shao Annie, Avdulov Svetlana, Herrera Jeremy, Aboudehen Karam, Pontoglio Marco, Igarashi Peter

Abstract excerpt

BACKGROUND: Mutation of HNF1B, the gene encoding transcription factor HNF-1β, is one cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by tubular cysts, renal fibrosis, and progressive decline in renal function. HNF-1β has also been implicated in epithelial-mesenchymal transition (EMT) pathways, and sustained EMT is associated with tissue fibrosis. The mechanism whereby...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial-Mesenchymal Transition
Share to Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Nuclear Factor 1-beta

Share to Hyperuricemia

Share to Kidney Diseases

Share to Transforming Growth Factor beta

Share to Twist-Related Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 30097458
DOI: 10.1681/ASN.2018040437
PMCID: PMC6171276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of Fibrosis in HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease.PMID 30097458Read ↗

Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease.Semantic proximity Read ↗

New insights into the role of HNF-1β in kidney (patho)physiology.Semantic proximity Read ↗

Role of transcription factor hepatocyte nuclear factor-1β in polycystic kidney disease.Semantic proximity Read ↗

Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous <i>HNF1B</i> -associated dysplastic kidney malformationsSemantic proximity Read ↗

HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes.Semantic proximity Read ↗

Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transportersSemantic proximity Read ↗

Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA.Semantic proximity Read ↗

Emerging role of Twist1 in fibrotic diseasesSemantic proximity Read ↗

Hepatocyte nuclear factor 1β controls nephron tubular developmentSemantic proximity Read ↗

Mechanisms of tubulointerstitial fibrosis.Semantic proximity Read ↗

Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis.Semantic proximity Read ↗

Hepatocyte nuclear factor-1β regulates Wnt signaling through genome-wide competition with β-catenin/lymphoid enhancer binding factor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.