Article
Mutated NPM1 in patients with acute myeloid leukemia in remission and relapse.
Leukemia & lymphoma - 1 Jun 2014
Jain Preetesh, Kantarjian Hagop, Patel Keyur, Faderl Stefan, Garcia-Manero Guillermo, Benjamini Ohad, Borthakur Gautam, Pemmaraju Naveen, Kadia Tapan, Daver Naval, Nazha Aziz, Luthra Raja, Pierce Sherry, Cortes Jorge, Ravandi Farhad
Abstract excerpt
Patients with newly diagnosed AML (n = 360) including 137 (38%) with normal karyotype (NK) were evaluated. Overall, 60 (16.6%) patients, including 46 of the 137 (33.5%) NK patients, had NPM1 mutation at baseline. Thirty-nine patients (30 NK) had available NPM1 status at the time of complete remission (CR) and all (100%) were negative for mutated NPM1. Among the patients with mutated NPM1 at baseline, 10/39...
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