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Prognostic impact of early minimal residual disease combined with complete molecular evaluation in acute myeloid leukemia with mutated NPM1: a single center study.

Leukemia & lymphoma - 1 Sept 2022

Memoli Mara, Genthon Alexis, Favale Fabrizia, Lapusan Simona, Johnson Natacha, Adaeva Rosa, Deswarte Caroline, Battipaglia Giorgia, Malard Florent, Duléry Rémy, Brissot Eolia, Banet Anne, Van de Wyngaert Zoé, Mohty Mohamad, Delhommeau François, Legrand Ollivier, Hirsch Pierre

Abstract excerpt

We evaluated prognostic factors in 83 intensively treated adult patients with NPM1 mutated AML. Targeted next-generation sequencing revealed high frequency of co-mutations in epigenetic modifiers or proliferation pathways. NPM1 minimal residual disease (MRD), assessed in bone marrow by specific polymerase chain reaction after one chemotherapy course, was >0.01% in 50 patients considered poor responders (PR). On...

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PMID: 35459427
DOI: 10.1080/10428194.2022.2064987

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Prognostic impact of early minimal residual disease combined with complete molecular evaluation in acute myeloid leukemia with mutated NPM1: a single center study.PMID 35459427Read ↗

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