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Article

A tumor suppressor function for caspase-2

11 Mar 2009

Abstract excerpt

Apoptosis is mediated by the caspase family of proteases that act as effectors of cell death by cleaving many cellular substrates. Caspase-2 is one of the most evolutionarily conserved caspases, yet its physiological function has remained enigmatic because caspase-2-deficient mice develop normally and are viable. We report here that the caspase-2(-/-) mouse embryonic fibroblasts (MEFs) show increased...

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PMID: 19279217
DOI: 10.1073/pnas.0811928106

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