Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PIDDosome-independent tumor suppression by Caspase-2

18 May 2012

Abstract excerpt

The PIDDosome, a multiprotein complex constituted of the 'p53-induced protein with a death domain (PIDD), 'receptor-interacting protein (RIP)-associated ICH-1/CED-3 homologous protein with a death domain' (RAIDD) and pro-Caspase-2 has been defined as an activating platform for this apoptosis-related protease. PIDD has been implicated in p53-mediated cell death in response to DNA damage but also in DNA repair and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22595758
DOI: 10.1038/cdd.2012.54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIDDosome-independent tumor suppression by Caspase-2PMID 22595758Read ↗

A role for caspase 2 and PIDD in the process of p53-mediated apoptosisSemantic proximity Read ↗

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.Semantic proximity Read ↗

Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulationSemantic proximity Read ↗

Multiple cell death pathways as regulators of tumour initiation and progressionSemantic proximity Read ↗

Caspases and cancer.Semantic proximity Read ↗

Caspase-2 as a master regulator of genomic stability.Semantic proximity Read ↗

Requirement for aspartate-cleaved bid in apoptosis signaling by DNA-damaging anti-cancer regimens.Semantic proximity Read ↗

FADD as a key molecular player in cancer progressionSemantic proximity Read ↗

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.Semantic proximity Read ↗

E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.Semantic proximity Read ↗

PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF–caspase 8–GSDMD/E axis in ovarian cancerSemantic proximity Read ↗

Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.