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Article

Caspase-2 as a master regulator of genomic stability.

Trends in cell biology - 1 Sept 2021

Kopeina Gelina S, Zhivotovsky Boris

Abstract excerpt

Genomic instability underlies genesis and the development of various types of cancer. During tumorigenesis, cancer initiating cells assume a set of features, which allow them to survive and proliferate. Different mutations and chromosomal alterations promote a selection of the most aggressive cancer clones that worsen the prognosis of the disease. Despite that caspase-2 was described as a protease fulfilling an...

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Identifiers

PMID: 33752921
DOI: 10.1016/j.tcb.2021.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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