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Article

Spindle assembly checkpoint-related failure perturbs early embryonic divisions and reduces reproductive performance of LT/Sv mice.

Reproduction (Cambridge, England) - 1 Jun 2009

Maciejewska Zuzanna, Polanski Zbigniew, Kisiel Katarzyna, Kubiak Jacek Z, Ciemerych Maria A

Abstract excerpt

The phenotype of the LT/Sv strain of mice is manifested by abnormalities in oocyte meiotic cell-cycle, spontaneous parthenogenetic activation, teratomas formation, and frequent occurrence of embryonic triploidy. These abnormalities lead to the low rate of reproductive success. Recently, metaphase I arrest of LT/Sv oocytes has been attributed to the inability to timely inactivate the spindle assembly checkpoint...

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Identifiers

PMID: 19279200
DOI: 10.1530/REP-09-0011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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