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Article

Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease.

Human molecular genetics - 1 Jun 2009

Zhu Guohua, Gulsvik Amund, Bakke Per, Ghatta Srinivas, Anderson Wayne, Lomas David A, Silverman Edwin K, Pillai Sreekumar G

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is characterized by airway epithelial damage, bronchoconstriction, parenchymal destruction and mucus hypersecretion. Upon activation by a broad range of stimuli, transient receptor potential vanilloid 4 (TRPV4) functions to control airway epithelial cell volume and epithelial and endothelial permeability; it also triggers bronchial smooth muscle contraction and...

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Source

Identifiers

PMID: 19279160
DOI: 10.1093/hmg/ddp111

Genes

TRPV4
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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