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Article

Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma.

The Journal of biological chemistry - 3 Sept 2010

Cantero-Recasens Gerard, Gonzalez Juan R, Fandos César, Duran-Tauleria Enric, Smit Lidwien A M, Kauffmann Francine, Antó Josep M, Valverde Miguel A

Abstract excerpt

Transient receptor potential cation channels of the vanilloid subfamily (TRPV) participate in the generation of Ca(2+) signals at different locations of the respiratory system, thereby controlling its correct functioning. TRPV1 expression and activity appear to be altered under pathophysiological conditions such as chronic cough and airway hypersensitivity, whereas TRPV4 single nucleotide polymorphisms (SNP) are...

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Identifiers

PMID: 20639579
DOI: 10.1074/jbc.C110.159491
PMCID: PMC2934619

Genes

TRPV1
TRPV4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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