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Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach.

Blood - 21 May 2009

Trégouët David-Alexandre, Heath Simon, Saut Noémie, Biron-Andreani Christine, Schved Jean-François, Pernod Gilles, Galan Pilar, Drouet Ludovic, Zelenika Diana, Juhan-Vague Irène, Alessi Marie-Christine, Tiret Laurence, Lathrop Mark, Emmerich Joseph, Morange Pierre-Emmanuel

Abstract excerpt

Venous thromboembolism (VTE) is a complex disease that has a major genetic component of risk. To identify genetic factors that may modify the risk of VTE, we conducted a genome-wide association study by analyzing approximately 317 000 single nucleotide polymorphisms (SNPs) in 453 VTE cases and 1327 controls. Only 3 SNPs located in the FV and ABO blood group genes were found associated with VTE at a genome-wide...

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Identifiers

PMID: 19278955
DOI: 10.1182/blood-2008-11-190389

Genes

ABO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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