Article
Hypertension exacerbates coronary artery disease in transgenic hyperlipidemic Dahl salt-sensitive hypertensive rats.
Molecular medicine (Cambridge, Mass.) - 1 Dec 2001
Herrera V M, Didishvili T, Lopez L V, Zander K, Traverse S, Gantz D, Herscovitz H, Ruiz-Opazo N
Abstract excerpt
BACKGROUND: The mechanisms underlying the known interaction of two complex polygenic traits, hypertension and hyperlipidemia, resulting in exacerbation of coronary artery disease have not been elucidated. Identification of critical pathways underlying said exacerbation could identify mechanism-based targets for intervention and prevention. MATERIALS AND METHODS: To investigate hypertension- atherosclerosis...
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