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Article

Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts.

Journal of biomedical science - 5 Feb 2009

Wu Yi-Hsuan, Cheng Mei-Ling, Ho Hung-Yao, Chiu Daniel Tsun-Yee, Wang Tzu-Chien V

Abstract excerpt

Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition. Here, we show that ectopic expression of hTERT stimulates telomerase activity and prevents...

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Identifiers

PMID: 19272180
DOI: 10.1186/1423-0127-16-18
PMCID: PMC2653519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts.PMID 19272180Read ↗

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Telomerase maintains telomere structure in normal human cells.Semantic proximity Read ↗

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