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Article

RNA modulators of complex phenotypes in mammalian cells.

PloS one - 1 Jan 2009

Lai Angela, Cairns Murray J, Tran Nham, Zhang Hong-Ping, Cullen Lara, Arndt Greg M

Abstract excerpt

RNA-mediated gene silencing, in the form of RNA interference (RNAi) or microRNAs (miRNAs) has provided novel tools for gene discovery and validation in mammalian cells. Here, we report on the construction and application of a random small RNA expression library for use in identifying small interfering RNA (siRNA) effectors that can modify complex cellular phenotypes in mammalian cells. The library is based in a...

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Identifiers

PMID: 19270743
DOI: 10.1371/journal.pone.0004758
PMCID: PMC2650256

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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