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Article

Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components.

Nucleic acids research - 19 Aug 2005

Jazag Amarsanaa, Kanai Fumihiko, Ijichi Hideaki, Tateishi Keisuke, Ikenoue Tsuneo, Tanaka Yasuo, Ohta Miki, Imamura Jun, Guleng Bayasi, Asaoka Yoshinari, Kawabe Takao, Miyagishi Makoto, Taira Kazunari, Omata Masao

Abstract excerpt

Although RNA interference (RNAi) is a popular technique, no method for simultaneous silencing of multiple targets by small-hairpin RNA (shRNA)-expressing RNAi vectors has yet been established. Although gene silencing can be achieved by synthetic small-interfering RNA (siRNA) duplexes, the approach is transient and largely dependent on the transfection efficiency of the host cell. We offer a solution: a simple,...

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PMID: 16113239
DOI: 10.1093/nar/gni130
PMCID: PMC1188087

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