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Article

Identification of small molecules that suppress microRNA function and reverse tumorigenesis.

The Journal of biological chemistry - 6 Aug 2010

Watashi Koichi, Yeung Man Lung, Starost Matthew F, Hosmane Ramachandra S, Jeang Kuan-Teh

Abstract excerpt

MicroRNAs (miRNAs) act in post-transcriptional gene silencing and are proposed to function in a wide spectrum of pathologies, including cancers and viral diseases. Currently, to our knowledge, no detailed mechanistic characterization of small molecules that interrupt miRNA pathways have been reported. In screening a small chemical library, we identified compounds that suppress RNA interference activity in...

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Identifiers

PMID: 20529860
DOI: 10.1074/jbc.M109.062976
PMCID: PMC2915707

Genes

AGO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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