Article
A model comparison of COMT effects on central processing of affective stimuli.
NeuroImage - 1 Jul 2009
Puls Imke, Mohr Johannes, Wrase Jana, Vollstädt-Klein Sabine, Leménager Tagrid, Vollmert Christian, Rapp Michael, Obermayer Klaus, Heinz Andreas, Smolka Michael N
Abstract excerpt
The number of studies on imaging genetics has risen considerably over the last few years, and haplotypes are being increasingly applied as a model to increase the explained variance in functional brain activation. Haplotypes, however, are not always the preferable approach. While such highly complex models have a greater capacity for fitting data, they might also lead to over-fitting. This study compares...
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