Article
A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior.
PloS one - 1 Jan 2009
Williams Richard, Lim Jackie E, Harr Bettina, Wing Claudia, Walters Ryan, Distler Margaret G, Teschke Meike, Wu Chunlei, Wiltshire Tim, Su Andrew I, Sokoloff Greta, Tarantino Lisa M, Borevitz Justin O, Palmer Abraham A
Abstract excerpt
Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a approximately 475 kb tandem duplication on chromosome 17 that includes Glo1 (30,174,390-30,651,226 Mb; mouse genome build 36). We developed a PCR-based strategy and used...
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