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Article

A Giant GTPase, Very Large Inducible GTPase-1, Is Inducible by IFNs

1 Aug 2003

Abstract excerpt

The complex, partially overlapping, cellular responses to IFN type I (IFN-alpha and -beta) and IFN type II (IFN-gamma) involve several hundred genes that can be largely classified in terms of specific cellular programs functional in innate and adaptive immunity. Among these programs are previously unconsidered mechanisms of cell-autonomous resistance against various pathogens mediated by dedicated, largely novel...

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PMID: 12874213
DOI: 10.4049/jimmunol.171.3.1255

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