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Article

C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.

FEBS letters - 1 Apr 2017

Jin Nana, Wu Yue, Xu Wen, Gong Cheng-Xin, Iqbal Khalid, Liu Fei

Abstract excerpt

Glycogen synthase kinase-3β (GSK-3β) is the major tau kinase. Its phosphorylation at Ser9 suppresses the activity. In Alzheimer's disease (AD) brain, GSK-3β is truncated at the C terminus by overactivated calpain I, leading to an increase in its activity. However, the effect of truncation on its phosphorylation is unknown. We found here that in AD brain and in cultured cells, C-terminally truncated GSK-3β is less...

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Identifiers

PMID: 28267204
DOI: 10.1002/1873-3468.12617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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