Article
The role of acetylation sites in the regulation of p53 activity.
Molecular biology reports - 1 Jan 2020
Wang Yun, Chen Yaqi, Chen Qiang, Zhang Xiuyuan, Wang Hongye, Wang Zhonghua, Wang Jian, Tian Chunyan
Abstract excerpt
As a "genomic guardian", p53 mainly functions as a transcription factor that regulates downstream targets responsible for cell fate control, and the activity of p53 is tightly regulated by a complex network that include an abundance of post-translational modifications. Notably, acetylation of p53 at many positions has been demonstrated to play a major role in accurate p53 regulation and cell fate determination....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.