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Article

GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers.

Oncotarget - 30 Aug 2016

Ko How-Wen, Lee Heng-Huan, Huo Longfei, Xia Weiya, Yang Cheng-Chieh, Hsu Jennifer L, Li Long-Yuan, Lai Chien-Chen, Chan Li-Chuan, Cheng Chien-Chia, Labaff Adam M, Liao Hsin-Wei, Lim Seung-Oe, Li Chia-Wei, Wei Yongkun, Nie Lei, Yamaguchi Hirohito, Hung Mien-Chie

Abstract excerpt

During the process of tumorigenesis, inactivation of tumor suppressors is a critical step. EZH2, a histone methyltransferase, promotes cell growth and migration through catalyzing trimethylation of histone H3 at Lys 27 (H3K27me3) and plays an important role in tumorigenesis. Its expression can be controlled by phosphorylation. However, the regulation of EZH2 activity by tumor suppressor kinase is not well...

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Identifiers

PMID: 27494834
DOI: 10.18632/oncotarget.11008
PMCID: PMC5302978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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