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Article

Involvement of der(12)t(12;21)(p13;q22) and as well as additional rearrangements of chromosome 12 homolog in ETV6/RUNX1-positive acute lymphoblastic leukemia.

Cancer genetics and cytogenetics - 1 Apr 2009

Stanchescu Racheli, Betts David R, Rechavi Gideon, Amariglio Ninette, Trakhtenbrot Luba

Abstract excerpt

The t(12;21) translocation is the most common translocation in childhood B-precursor ALL. Because G-banding cannot detect the cryptic t(12;21), the full characterization of additional aberrations involving chromosome 12 is often difficult. Spectral karyotyping (SKY) can distinguish a der(12)t(12;21) chromosome from a nonrearranged chromosome 12. We therefore applied SKY on an unselected series of 14 patients...

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Share to Chromosomes, Human, Pair 12
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Cytogenetic Analysis

Share to Models, Biological

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Translocation, Genetic

Source

Identifiers

PMID: 19264230
DOI: 10.1016/j.cancergencyto.2008.12.003

Genes

ETV6
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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