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Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma

1 Jan 2001

Abstract excerpt

Multicolour spectral karyotyping (SKY) was performed on primary tumour specimens from 100 patients with multiple myeloma (MM) that showed complex clonal chromosome aberrations not fully characterized by G-banding. In this study, SKY was able to identify or revise translocations with breakpoints involving 14q32, 11q13 or 8q24 in 32 patients (32%). Five new recurring translocations were identified, two of which...

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Share to Genomic variations and chromosomal abnormalities
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PMID: 11167798
DOI: 10.1046/j.1365-2141.2001.02546.x

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