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Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G‐banding

1 Jan 2002

Abstract excerpt

Seventy uniformly treated children with acute lymphoblastic leukemia were analysed for chromosomal abnormalities with conventional G-banding, spectral karyotyping (SKY) and interphase fluorescent in situ hybridisation (FISH) using probes to detect MLL, BCR/ABL, TEL/AML1 rearrangements and INK4 locus deletions. Numerical and/or structural changes could be identified in 80% of the patients by the use of molecular...

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PMID: 11952819
DOI: 10.1034/j.1600-0609.2002.00547.x

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