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Article

Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2009

Mullendore Michael E, Koorstra Jan-Bart, Li Yue-Ming, Offerhaus G Johan, Fan Xing, Henderson Clark M, Matsui William, Eberhart Charles G, Maitra Anirban, Feldmann Georg

Abstract excerpt

PURPOSE: Aberrant activation of the Notch signaling pathway is commonly observed in human pancreatic cancer, although the mechanism(s) for this activation has not been elucidated. EXPERIMENTAL DESIGN: A panel of 20 human pancreatic cancer cell lines was profiled for the expression of Notch pathwa...

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Source

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Identifiers

PMID: 19258443
DOI: 10.1158/1078-0432.CCR-08-2004
PMCID: PMC2711441

Genes

DLL3
NOTCH1
DLL4
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19258443-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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