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Article

Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway.

Cancer research - 15 Mar 2009

Wang Zhiwei, Li Yiwei, Kong Dejuan, Banerjee Sanjeev, Ahmad Aamir, Azmi Asfar Sohail, Ali Shadan, Abbruzzese James L, Gallick Gary E, Sarkar Fazlul H

Abstract excerpt

Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most difficult human malignancies to treat due, in part, to de novo and acquired chemoresistance and radioresistance. Gemcitabine alone or in combination with other conventional therapeutics is the standard of care for the treatment of advanced PC without any significant improvement in the overall survival of patients diagnosed with...

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Identifiers

PMID: 19276344
DOI: 10.1158/0008-5472.CAN-08-4312
PMCID: PMC2657919

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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