The Notch Pathway Is Important in Maintaining the Cancer Stem Cell Population in Pancreatic Cancer

Abstract excerpt

BACKGROUND: Pancreatic cancer stem cells (CSCs) represent a small subpopulation of pancreatic cancer cells that have the capacity to initiate and propagate tumor formation. However, the mechanisms by which pancreatic CSCs are maintained are not well understood or characterized. METHODS: Expression of Notch receptors, ligands, and Notch signaling target genes was quantitated in the CSC and non-CSC populations from...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biological Research and Disease Studies
• Share to Cancer Cells and Metastasis
• Share to Developmental Biology and Gene Regulation