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Article

Common Activation of Canonical Wnt Signaling in Pancreatic Adenocarcinoma

6 Nov 2007

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is an extremely aggressive malignancy, which carries a dismal prognosis. Activating mutations of the Kras gene are common to the vast majority of human PDA. In addition, recent studies have demonstrated that embryonic signaling pathway such as Hedgehog and Notch are inappropriately upregulated in this disease. The role of another embryonic signaling pathway, namely the...

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PMID: 17982507
DOI: 10.1371/journal.pone.0001155

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