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Article

Aspartate β-Hydroxylase expression promotes a malignant pancreatic cellular phenotype.

Oncotarget - 20 Jan 2015

Dong Xiaoqun, Lin Qiushi, Aihara Arihiro, Li Yu, Huang Chiung-Kuei, Chung Waihong, Tang Qi, Chen Xuesong, Carlson Rolf, Nadolny Christina, Gabriel Gregory, Olsen Mark, Wands Jack R

Abstract excerpt

Pancreatic cancer (PC) is one of the leading causes of cancer related deaths due to aggressive progression and metastatic spread. Aspartate β-hydroxylase (ASPH), a cell surface protein that catalyzes the hydroxylation of epidermal growth factor (EGF)-like repeats in Notch receptors and ligands, is highly overexpressed in PC. ASPH upregulation confers a malignant phenotype characterized by enhanced cell...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25483102
DOI: 10.18632/oncotarget.2840
PMCID: PMC4359229

Genes

ASPH
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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