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Article

Mechanism of spindle pole organization and instability in human oocytes

10 Feb 2022

Abstract excerpt

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown. We found that NUMA (nuclear mitotic apparatus protein)-mediated clustering of microtubule minus ends focused the spindle poles in human, bovine, and porcine oocytes and in mouse oocytes depleted of acentriolar microtubule-organizing centers...

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PMID: 35143306
DOI: 10.1126/science.abj3944

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