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Article

Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis.

Journal of cell science - 1 Feb 1995

Compton D A, Luo C

Abstract excerpt

NuMA is a 236 kDa intranuclear protein that is distributed into each daughter cell during mitosis through association with the pericentrosomal region of the mitotic spindle. NuMA's interaction with the microtubules of the mitotic spindle is mediated through its 45 kDa carboxyl-terminal globular tail, and there is indirect evidence suggesting that NuMA's interaction with the mitotic spindle is controlled in a...

Topics

Animals
Antigens, Nuclear
Base Sequence
CDC2 Protein Kinase
Cell Cycle Proteins
Cell Line
Cricetinae
DNA Primers
Humans
Mitosis
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Matrix-Associated Proteins

Nuclear Proteins

Spindle Apparatus

Source

Identifiers

PMID: 7769006
DOI: 10.1242/jcs.108.2.621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7769006-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis.PMID 7769006Read ↗

Phosphorylation of NuMA by Aurora-A kinase in PC-3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization.Semantic proximity Read ↗

Numb Regulates Stability and Localization of the Mitotic Kinase PLK1 and Is Required for Transit through MitosisSemantic proximity Read ↗

NuMA is required for proper spindle assembly and chromosome alignment in prometaphaseSemantic proximity Read ↗

Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors.Semantic proximity Read ↗

NudC deacetylation regulates mitotic progression.Semantic proximity Read ↗

Requirements for NuMA in maintenance and establishment of mammalian spindle poles.Semantic proximity Read ↗

Rae1 interaction with NuMA is required for bipolar spindle formation.Semantic proximity Read ↗

NuMA interaction with chromatin is vital for proper nuclear architecture in human cellsSemantic proximity Read ↗

The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.Semantic proximity Read ↗

Mitotic regulation of protein 4.1R involves phosphorylation by cdc2 kinase.Semantic proximity Read ↗

NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle polesSemantic proximity Read ↗

Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein.Semantic proximity Read ↗

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