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Article

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies

30 Oct 2002

Abstract excerpt

Thrombocytopenia is a common medical problem for which the main treatment is platelet transfusion. Given the increasing use of platelets and the declining donor population, identification of a safe and effective platelet growth factor could improve the management of thrombocytopenia. Thrombopoietin (TPO), the c-Mpl ligand, is the primary physiologic regulator of megakaryocyte and platelet development. Since the...

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PMID: 12411315
DOI: 10.1182/blood.v100.10.3457

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