Article
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
Blood - 14 Jun 2012
Debrincat Marlyse A, Josefsson Emma C, James Chloé, Henley Katya J, Ellis Sarah, Lebois Marion, Betterman Kelly L, Lane Rachael M, Rogers Kelly L, White Michael J, Roberts Andrew W, Harvey Natasha L, Metcalf Donald, Kile Benjamin T
Abstract excerpt
Mature megakaryocytes depend on the function of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of platelet shedding. Despite this, loss of Bcl-x(L) does not prevent the growth and maturation of megakaryocytes, suggesting redundancy with other prosurvival proteins. We therefore generated mice with a megakaryocyte-specific deletion of Mcl-1, which is known to...
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