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Article

A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis.

Blood - 1 Jun 2006

Nakamura Takanori, Miyakawa Yoshitaka, Miyamura Atsushi, Yamane Akiko, Suzuki Hidenori, Ito Mamoru, Ohnishi Yasuyuki, Ishiwata Norihisa, Ikeda Yasuo, Tsuruzoe Nobutomo

Abstract excerpt

NIP-004 is a novel synthetic compound developed to display human thrombopoietin (TPO) receptor (c-Mpl) agonist activity. NIP-004 displays species specificity, stimulating proliferation or differentiation of human c-Mpl-expressing cells such as UT-7/TPO and human CD34(+) cells but not murine c-Mpl-expressing cells or cynomolgus monkey cells. To test the mechanism of its action, we constructed mutant forms of...

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Source

Identifiers

PMID: 16484588
DOI: 10.1182/blood-2005-11-4433

Genes

TPO
NOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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