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Article

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.

Blood - 1 May 2005

Metcalf Donald, Carpinelli Marina R, Hyland Craig, Mifsud Sandra, Dirago Ladina, Nicola Nicos A, Hilton Douglas J, Alexander Warren S

Abstract excerpt

Mpl(-/-) mice bearing the Plt3 or Plt4 mutations in the c-Myb gene exhibit thrombopoietin (TPO)-independent supraphysiological platelet production accompanied by excessive megakaryocytopoiesis and defective erythroid and lymphoid cell production. To better define the cellular basis for the thrombocytosis in these mice, we analyzed the production and characteristics of megakaryocytes and their progenitors....

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Identifiers

PMID: 15665109
DOI: 10.1182/blood-2004-12-4806

Genes

TPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.PMID 15665109Read ↗

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-MplSemantic proximity Read ↗

Hematopoietic Deficiencies in c‐mpl and TPO Knockout MiceSemantic proximity Read ↗

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Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferationSemantic proximity Read ↗

Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.Semantic proximity Read ↗

Thrombocytosis as a response to high interleukin-6 levels in cGMP-dependent protein kinase I mutant mice.Semantic proximity Read ↗

Granulocyte-macrophage colony-stimulating factor is not responsible for residual thrombopoiesis in mpl null mice.Semantic proximity Read ↗

Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia.Semantic proximity Read ↗

Increased incidence and analysis of emperipolesis in megakaryocytes of the mouse mutant gunmetal.Semantic proximity Read ↗

The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.Semantic proximity Read ↗

The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor.Semantic proximity Read ↗

Mice rendered severely deficient in megakaryocytes through targeted gene deletion of the thrombopoietin receptor c-Mpl have a normal skeletal phenotype.Semantic proximity Read ↗

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