Article

<i>TECTB</i> Variants Reveal Tectorial Membrane Vulnerability in Dominant Non-Syndromic Hearing Loss

2025-08-14

Abstract excerpt

Identifying new genes responsible for non-syndromic hearing loss remains a critical goal as many patients still lack a molecular diagnosis despite comprehensive genetic testing. The tectorial membrane (TM) is a specialized acellular matrix of the inner ear, essential for stimulating mechanosensitive hair cell stereocilia bundles and maintaining frequency tuning and auditory sensitivity. Although mutations in genes...

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Literature Corpus work: 0b9078d0-ebd9-539b-8add-ced5bb265683
DOI: 10.1101/2025.08.13.25333146

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