Article
The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Feb 2009
Szabó Nora-Emöke, Zhao Tianyu, Zhou Xunlei, Alvarez-Bolado Gonzalo
Abstract excerpt
The specification of the intricate neuronal assemblies that characterize the forebrain is not well understood. The ventral spinal cord is specified through a concentration gradient of Sonic hedgehog (Shh) protein secreted by the notochord. Shh is expressed also in the forebrain neuroepithelium (neural Shh) and the underlying notochord and prechordal plate. Neural Shh is essential for the development of the...
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