Article
Functional complementation of UvsX and UvsY mutations in the mediation of T4 homologous recombination.
Nucleic acids research - 1 Apr 2009
Farb Joshua N, Morrical Scott W
Abstract excerpt
Bacteriophage T4 homologous recombination events are promoted by presynaptic filaments of UvsX recombinase bound to single-stranded DNA (ssDNA). UvsY, the phage recombination mediator protein, promotes filament assembly in a concentration-dependent manner, stimulating UvsX at stoichiometric concentrations but inhibiting at higher concentrations. Recent work demonstrated that UvsX-H195Q/A mutants exhibit decreased...
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