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Article

The mutation R107Q alters mtSSB ssDNA compaction ability and binding dynamics.

Nucleic acids research - 10 Jun 2024

Martucci Martial, Moretton Amandine, Tarrés-Solé Aleix, Ropars Virginie, Lambert Louise, Vernet Patrick, Solà Maria, Falkenberg Maria, Farge Geraldine, van den Wildenberg Siet

Abstract excerpt

Mitochondrial single-stranded DNA-binding protein (mtSSB) is essential for mitochondrial DNA (mtDNA) replication. Recently, several mtSSB variants have been associated with autosomal dominant mitochondrial optic atrophy and retinal dystrophy. Here, we have studied at the molecular level the functional consequences of one of the most severe mtSSB variants, R107Q. We first studied the oligomeric state of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38742632
DOI: 10.1093/nar/gkae354
PMCID: PMC11162770

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