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Article

Deciphering the essentiality and function of SxSx motif in Mycobacterium tuberculosis UvrB.

Biochimie - 1 Mar 2020

Thakur Manoj, Muniyappa K

Abstract excerpt

The UvrB subunit is a central component of the UvrABC incision complex and plays a pivotal role in damage recognition, strand excision and repair synthesis. A conserved structural motif (the SxSx motif) present in UvrB is analogous to a similar motif (TxGx) in the helicases of superfamily 2, whose function is not fully understood. To elucidate the significance of the SxSx (Ser143-Val144-Ser145-Cys146) motif in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31923481
DOI: 10.1016/j.biochi.2020.01.003

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