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Multiprotein E. coli SSB-ssDNA complex shows both stable binding and rapid dissociation due to interprotein interactions.

Nucleic acids research - 22 Feb 2021

Naufer M Nabuan, Morse Michael, Möller Guðfríður Björg, McIsaac James, Rouzina Ioulia, Beuning Penny J, Williams Mark C

Abstract excerpt

Escherichia coli SSB (EcSSB) is a model single-stranded DNA (ssDNA) binding protein critical in genome maintenance. EcSSB forms homotetramers that wrap ssDNA in multiple conformations to facilitate DNA replication and repair. Here we measure the binding and wrapping of many EcSSB proteins to a single long ssDNA substrate held at fixed tensions. We show EcSSB binds in a biphasic manner, where initial wrapping...

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Identifiers

PMID: 33434279
DOI: 10.1093/nar/gkaa1267
PMCID: PMC7897507

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