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Article

Evidence for action of ribavirin through the hepatitis C virus RNA polymerase.

Journal of viral hepatitis - 1 Aug 2009

Cannon N A, Donlin M J, Mayes L M, Lyra A C, Di Bisceglie A M, Tavis J E

Abstract excerpt

Hepatitis C virus (HCV) infections are treated with interferon alpha plus ribavirin, but it is unknown how ribavirin works against HCV. Ribavirin is a guanosine analogue that can be a substrate for the viral RNA polymerase. HCV is genetically variable, and this genetic variation could affect the polymerase's use of ribavirin triphosphate. Thirteen patients infected with HCV who failed interferon alpha monotherapy...

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Share to Antiviral Agents
Share to DNA-Directed RNA Polymerases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Mutation, Missense

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Share to RNA, Viral

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Source

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Identifiers

PMID: 19243495
DOI: 10.1111/j.1365-2893.2009.01109.x
PMCID: PMC3153910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for action of ribavirin through the hepatitis C virus RNA polymerase.PMID 19243495Read ↗

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