Article
Ribavirin mode of action in chronic hepatitis C: from clinical use back to molecular mechanisms.
Liver international : official journal of the International Association for the Study of the Liver - 1 Dec 2008
Hofmann Wolf Peter, Herrmann Eva, Sarrazin Christoph, Zeuzem Stefan
Abstract excerpt
Ribavirin is an old broad-spectrum antiviral that is highly effective when used in combination with interferon-alpha and also as part of triple therapies containing new inhibitors of the hepatitis C virus (HCV) non-structural (NS)3/4 protease or HCV NS5B polymerase for the treatment of patients with chronic hepatitis C. However, the molecular mechanisms by which ribavirin enhances early and sustained virological...
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