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Article

Effects of mutagenic and chain-terminating nucleotide analogs on enzymes isolated from hepatitis C virus strains of various genotypes.

Antimicrobial agents and chemotherapy - 1 Jun 2008

Heck Julie A, Lam Angela M I, Narayanan Nirupama, Frick David N

Abstract excerpt

The development of effective therapies for hepatitis C virus (HCV) must take into account genetic variation among HCV strains. Response rates to interferon-based treatments, including the current preferred treatment of pegylated alpha interferon administered with ribavirin, are genotype specific. Of the numerous HCV inhibitors currently in development as antiviral drugs, nucleoside analogs that target the...

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Identifiers

PMID: 18391043
DOI: 10.1128/AAC.01496-07
PMCID: PMC2415805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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