Article
Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10.
Human mutation - 1 Mar 2009
Liang Xueying, Slifer Michael, Martin Eden R, Schnetz-Boutaud Nathalie, Bartlett Jackie, Anderson Brent, Züchner Stephan, Gwirtsman Harry, Gilbert John R, Pericak-Vance Margaret A, Haines Jonathan L
Abstract excerpt
A broad region of chromosome 10 (chr10) has engendered continued interest in the etiology of late-onset Alzheimer Disease (LOAD) from both linkage and candidate gene studies. However, there is a very extensive heterogeneity on chr10. We converged linkage analysis and gene expression data using the concept of genomic convergence that suggests that genes showing positive results across multiple different data types...
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