DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR.

doi:10.1158/1055-9965.EPI-08-0916

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Article

DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2009

Tao Meng Hua, Shields Peter G, Nie Jing, Marian Catalin, Ambrosone Christine B, McCann Susan E, Platek Mary, Krishnan Shiva S, Xie Bin, Edge Stephen B, Winston Janet, Vito Dominica, Trevisan Maurizio, Freudenheim Jo L

Abstract excerpt

Aberrant promoter methylation is recognized as an important feature of breast carcinogenesis. We hypothesized that genetic variation of genes for methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR), two critical enzymes in the one-carbon metabolism, may alter DNA methylation levels and thus influence DNA methylation in breast cancer. We evaluated case-control association of MTHFR C677T,...

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Identifiers

PMID: 19240236
DOI: 10.1158/1055-9965.EPI-08-0916
PMCID: PMC3837294

Genes

MTHFR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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