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Article

Lack of significance of the BRCA2 promoter methylation status in different genotypes of the MTHFR a1298c polymorphism in ovarian cancer cases in Iran.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Darehdori Ahmad Shabanizadeh, Dastjerdi Mehdi Nikbakht, Dahim Hajar, Slahshoor Mohammadreza, Babazadeh Zahra, Taghavi Mohammad Mohsen, Taghipour Zahra, Gaafarineveh Hamidreza

Abstract excerpt

OBJECTIVE: Promoter methylation, which can be regulated by MTHFR activity, is associated with silencing of genes. In this study we evaluated the methylation status (type) of the BRCA2 promoter in ovarian cancer patients carrying different genotypes of the MTHFR gene (A or C polymorphisms at position 1298). METHODS: The methylation type of the BRCA2 promoter was evaluated using bisulfate-modified DNA in...

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Share to BRCA2 Protein
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Neoplasm Staging

Share to Ovarian Neoplasms

Share to Polymorphism, Restriction Fragment Length

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 22901131
DOI: 10.7314/apjcp.2012.13.5.1833

Genes

BRCA2
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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