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Article

p53 Deficiency Leads to Compensatory Up-Regulation of p16INK4a

25 Feb 2009

Abstract excerpt

p53-p21-cyclin-dependent kinase and p16(INK4a)-cyclin-dependent kinase pathways have parallel functions in preventing tumorigenesis. In cancer patients, tumor suppressor p53 is frequently inactivated through mutations, whereas p16(INK4a) is silenced through promoter methylation. However, the interaction between these two pathways is less well understood. Here, we report that p53 controls p16(INK4a) expression in...

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PMID: 19240179
DOI: 10.1158/1541-7786.mcr-08-0373

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