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Article

p16INK4A Positively Regulates p21WAF1 Expression by suppressing AUF1-dependent mRNA decay

23 Jul 2013

Abstract excerpt

BACKGROUND: p16(INK4a) and p21(WAF1) are two independent cyclin-dependent kinase inhibitors encoded by the CDKN2A and CDKN1A genes, respectively. p16(INK4a) and p21(WAF1) are similarly involved in various anti-cancer processes, including the regulation of the critical G1 to S phase transition of the cell cycle, senescence and apoptosis. Therefore, we sought to elucidate the molecular mechanisms underlying the...

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PMID: 23894605
DOI: 10.1371/journal.pone.0070133

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