Article
C<scp>ell</scp> C<scp>ycle</scp> D<scp>ysregulation in</scp> O<scp>ral</scp> C<scp>ancer</scp>
1 Jan 2002
Abstract excerpt
The dysregulation of the molecular events governing cell cycle control is emerging as a central theme of oral carcinogenesis. Regulatory pathways responding to extracellular signaling or intracellular stress and DNA damage converge on the cell cycle apparatus. Abrogation of mitogenic and anti-mitogenic response regulatory proteins, such as the retinoblastoma tumor suppressor protein (pRB), cyclin D1,...